Fisetin
is a unique flavonoid compound found naturally in many fruits and vegetables
including strawberries, blueberries and the skin of cucumbers. A wealth of
scientific research now explains how a diet packed with raw fruits and
vegetables can help prevent amyloid plaque formation in the aging brain and can
promote the early destruction of cancer cells by triggering the body's innate
immune response. Researchers reporting in the journal Neuroscience Letters found that fisetin is neuro-protective and
helps to maintain normal memory processes while inhibiting plaque formation
around synapses.
The International Journal of
Oncology has published the work of Chinese
scientists documenting how fisetin promotes the natural death of potentially
malignant breast cancer cells. Fisetin is rapidly emerging as a powerful tool
in the arsenal against a number of diseases associated with premature aging.
Fruits and vegetables in their natural state are typically packed with polyphenols; these polyphenols are structurally bioactive and target specific areas of the body or help to lower oxidative stress and inflammation that is behind many disease processes. The brain is particularly sensitive to stress from a high rate of metabolism necessary to oxygenate and fuel the sensitive neurons that control memory and cognition.
Fruits and vegetables in their natural state are typically packed with polyphenols; these polyphenols are structurally bioactive and target specific areas of the body or help to lower oxidative stress and inflammation that is behind many disease processes. The brain is particularly sensitive to stress from a high rate of metabolism necessary to oxygenate and fuel the sensitive neurons that control memory and cognition.
Fisetin Helps Prevent Inflammation
in the Brain to Boost Memory and Cognition
Researchers have found that fisetin
operates in a very specific pathway to boost nerve cell glutathione levels and
to reduce one of the most damaging free radicals, peroxynitrite. Scientists
have determined that the natural compound protects nerve cells from damage during
stroke, while at the same time maintaining vital energy production in the
brain. Fisetin also prevents excess activation of specialized glial cells in
the brain that helps deter inflammatory nerve damage, excitotoxicity, and
declining neurological health. And fisetin reduces amyloid
beta fiber accumulation to improve memory and thwart cognitive decline.
In a separate body of research, scientists examined the effect of fisetin from dietary and supplemental sources on breast cancer programmed cell death. Cancer cells normally are detected and destroyed by an alert immune system response. Inflammatory messengers such as TNFa (tumor necrosis factor alpha) allow cancer cells to become cloaked and invisible to our immune system, which prevents cancer cell death through the process known as apoptosis. Fisetin negates the damaging effect of TNFa, reducing systemic inflammation and enabling the normal immune response.
Many health-conscious individuals may not be immediately familiar with fisetin, although they already consume therapeutic quantities from their healthy dietary choices.
Nutrition experts recommend including fruits such as strawberries and mangoes as a source of dietary fisetin or supplementing with 50 mg per day to boost memory and high-level brain function and to promote natural cancer cell death.
References:
http://www.wellnessresources.com/health/articles/fisetin_demonstrates...
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2775892/?tool=pubmed
http://www.ncbi.nlm.nih.gov/pubmed/18761054
http://www.ncbi.nlm.nih.gov/pubmed/21922137
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